![]() However, there is only limited literature on the potential therapeutic use of saffron for ADHD. Given that, first, both dopamine and noradrenaline are the core neurotransmitters associated with ADHD, and second, saffron extract is a safe, natural substance, thus alleviating parental fears regarding the stimulant-drug based treatment of ADHD, it seems plausible to test whether saffron has some potential to treat ADHD. Indeed, saffron has several psychoactive properties, and acts on NDMA and GABA receptors, facilitating dopamine, serotonin, and noradrenaline secretion. Furthermore, there is increasing evidence that saffron, probably due to some key constituents (namely, crocin, picrocrocin, and safranal) exerts protection of the central nervous system. Moreover, recent evidence also suggests that saffron may improve the lipid profile and help to modulate hypertension. Accordingly, saffron has been used to treat chronic diseases such as rheumatoid arthritis, inflammatory bowel diseases, Alzheimer’s, and several cancers (e.g., colon, stomach, breast, lung, and skin). Saffron is a spice extracted from saffron crocus (crocus sativus) that has traditionally been used as an additive and food colorant worldwide, but also as a natural remedy for several diseases given its anti-inflammatory and antioxidant properties. Within nutritional supplements, saffron has recently been postulated as one of the most interesting alternative treatments for ADHD. Accordingly, different authors have advocated for the use of alternative treatments such as neurofeedback, serious video games, and/or nutritional supplements. Although ADHD medications are safe, and the profile of side effects is usually mild, many parents and patients are reluctant to take these medications. ![]() Pharmacotherapy consists of stimulants (i.e., methylphenidate, lisdexamphetamine) or non-stimulant drugs (i.e., atomoxetine, guanfacine). Multimodal treatment, including pharmacotherapy, psychotherapy, and psychoeducation, is the treatment of choice for ADHD. ADHD symptoms typically encompass hyperactivity, inattention, and impulsivity. Attention Deficit/Hyperactivity Disorder (ADHD) is one of the most prevalent neurodevelopmental disorders among children, adolescents, and adults worldwide. ![]()
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